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Genetic variants an...
Genetic variants and family history predict prostate cancer similar to prostate-specific antigen
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Zheng, S. Lilly (author)
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Sun, Jielin (author)
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- Wiklund, Fredrik (author)
- Karolinska Institutet
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Gao, Zhengrong (author)
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- Stattin, Pär (author)
- Department of Surgical and Perioperative sciences, Urology and Andrology, Umeå University Hospital, Umeå
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Purcell, Lina D. (author)
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- Adami, Hans-Olov (author)
- Karolinska Institutet
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Hsu, Fang-Chi (author)
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Zhu, Yi (author)
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- Adolfsson, Jan (author)
- Karolinska Institutet
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- Johansson, Jan-Erik (author)
- Örebro universitet,Hälsoakademin
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Turner, Aubrey R. (author)
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Adams, Tamara S. (author)
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Liu, Wennuan (author)
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Duggan, David (author)
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Carpten, John D. (author)
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Chang, Bao-Li (author)
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Isaacs, William B. (author)
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Xu, Jianfeng (author)
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- Grönberg, Henrik (author)
- Karolinska Institutet
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Li, WN (author)
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(creator_code:org_t)
- 2009
- 2009
- English.
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In: Clinical Cancer Research. - 1078-0432 .- 1557-3265. ; 15:3, s. 1105-1111
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
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- PURPOSE: Although prostate-specific antigen (PSA) is the best biomarker for predicting prostate cancer, its predictive performance needs to be improved. Results from the Prostate Cancer Prevention Trial revealed the overall performance measured by the areas under curve of the receiver operating characteristic at 0.68. The goal of the present study is to assess the ability of genetic variants as a PSA-independent method to predict prostate cancer risk. EXPERIMENTAL DESIGN: We systematically evaluated all prostate cancer risk variants that were identified from genome-wide association studies during the past year in a large population-based prostate cancer case-control study population in Sweden, including 2,893 prostate cancer patients and 1,781 men without prostate cancer. RESULTS: Twelve single nucleotide polymorphisms were independently associated with prostate cancer risk in this Swedish study population. Using a cutoff of any 11 risk alleles or family history, the sensitivity and specificity for predicting prostate cancer were 0.25 and 0.86, respectively. The overall predictive performance of prostate cancer using genetic variants, family history, and age, measured by areas under curve was 0.65 (95% confidence interval, 0.63-0.66), significantly improved over that of family history and age (0.61%; 95% confidence interval, 0.59-0.62; P = 2.3 x 10(-10)). CONCLUSION: The predictive performance for prostate cancer using genetic variants and family history is similar to that of PSA. The utility of genetic testing, alone and in combination with PSA levels, should be evaluated in large studies such as the European Randomized Study for Prostate Cancer trial and Prostate Cancer Prevention Trial.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Urologi och njurmedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Urology and Nephrology (hsv//eng)
Keyword
- MEDICINE
- MEDICIN
- Oncology
- Onkologi
- Onkologi
- Oncology
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Zheng, S. Lilly
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Sun, Jielin
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Wiklund, Fredrik
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Gao, Zhengrong
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Stattin, Pär
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Purcell, Lina D.
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show more...
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Adami, Hans-Olov
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Hsu, Fang-Chi
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Zhu, Yi
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Adolfsson, Jan
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Johansson, Jan-E ...
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Turner, Aubrey R ...
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Adams, Tamara S.
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Liu, Wennuan
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Duggan, David
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Carpten, John D.
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Chang, Bao-Li
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Isaacs, William ...
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Xu, Jianfeng
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Grönberg, Henrik
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Li, WN
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Cancer and Oncol ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Urology and Neph ...
- Articles in the publication
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Clinical Cancer ...
- By the university
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Örebro University
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Umeå University
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Karolinska Institutet